Introduction
For individuals with chronic Lyme disease, searching for effective treatments can feel over the board. Of course, antibiotics can be the first line of treatment yet many individuals experience lingering symptoms such as fatigue, brain fog, joint pain, and immune disruption post the infection.
This is the place where herbal medicine steps in. One herb that has gained attention is Andrographis paniculata. It is also called the “King of Bitters.”
But how effective is it for Lyme? What role does it play in recovery? And Can it cure Lyme completely? Let us explore what the science says and how it is used in protocols and treatment for Lyme disease.
Why Andrographis for Lyme?
Why do you think this herb is important and popular for Chronic Lyme treatment?
Andrographis paniculata is not only a traditional remedy- but it has also become popular in the modern Lyme protocols. But is it useful?
- Antimicrobial activity: Lab studies show that Andrographis antibacterial properties and can also have good action against Borrelia burgdorferi bacteria. It does not definitely act like an antibiotic, but it may weaken the bacteria and support the immune system of the body.
- Immune Modulation: Chronic Lyme has a great impact on the immune system. Andrographis is known for modulation of the immune system. Basically, it aids in bringing back the balance.
- Anti- inflammatory properties: Inflammation is one of the major causes of Lyme symptoms. This also helps in easing symptoms such as joint pain, fatigue, and brain fog.
- Used in Herbal Protocols: Andrographis is used as a synergy in herbal protocols. It is used as a synergy in the Buhner Protocol.
Andrographis aids in attacking the bacteria, calming inflammation, and supporting immunity. Thereby to an extent aids in managing chronic Lyme symptoms.
The Science Behind Andrographis
Andrographis paniculata contains several active compounds, especially andrographolide, that are believed to drive its therapeutic effects. While most studies have been done in labs or animals, the early science is promising—especially when it comes to chronic infections like Lyme disease.
- Fights Borrelia burgdorferi bacteria
- Regulation of the Immune system
- Minimizes inflammation
- Neuroprotective Potential
The compounds in Andrographis may weaken Borrelia, calm inflammation, and help restore immune balance—making it a strong herbal candidate for chronic Lyme support, especially when used alongside other herbs.
How to Adverse Effects and Precautions
Safety and Adverse Effects:
SHORT- TERM–
- A systematic review found serious adverse events to be very rare (~0.02 per 1,000), while non-serious events like GI upset or rashes occur in about 10–25% of users .
- A 4-day Phase I trial in healthy adults showed no significant changes in blood tests; only grade 1 mild events like improved appetite or sleep
COMMON MILD SIDE EFFECTS–
- Gastrointestinal issues: nausea, diarrhea, dyspepsia, flatulence.
- Dermatologic reactions: rash, itchiness, urticaria; occasionally transient headache or fatigue.
- Rare allergic/anaphylactic reactions: the Australian TGA noted 300+ reports since 2005—including one fatality in 2024—particularly with herbal blends containing Echinacea.
PRECAUTIONS AND INTERACTIONS–
- Autoimmune conditions: Andrographis is immunostimulant—may exacerbate diseases like lupus or MS.
- Bleeding risk: May inhibit clotting—avoid taking anticoagulants or bleeding disorders.
- Blood pressure impact: Can lower BP — caution if you’re already taking antihypertensives .
- Drug metabolism: Alters clearance of drugs like theophylline, celecoxib, and glipizide — monitor when coadministered.
- Pregnancy/lactation: Avoid use during pregnancy (risk of miscarriage) and lactation due to limited safety data.
