
Lyme disease, which is transmitted through a tick bite can result in various clinical symptoms, such as joint pain, facial nerve paralysis, skin rashes, etc. Some patients may develop Post-Treatment Lyme Disease Syndrome (PTLDS) after antibiotic treatment and they experience brain fog, severe pain, sleep disorders, etc.
CBD (cannabidiol) is prescribed for many conditions, such as anxiety, chronic pain, etc. Can CBD help to relieve the symptoms of Lyme disease? In this blog, we will explore the therapeutic benefits of CBD and how it affects the treatment outcomes of Lyme disease patients.
What is CBD?
Cannabidiol is a natural ingredient, that is found in cannabis. It has been estimated that CBD promotes the growth of brain cells. CBD is indicated in various conditions, such as:
- Autoimmune conditions
- Metabolic disorders
- Mental health conditions
- Cardiovascular diseases
- Gastrointestinal disorders
CBD is a major component of marijuana, and is derived from the hemp plant. According to the World Health Organisation, CBD does not exhibit dependence potential.
CBD can come in the form of tinctures, patches, topical preparations, etc. Topical CBD can help to reduce the inflammation and relieve the muscle pain. Sublingual preparations of CBD, which is placed beneath the tongue allows the drug to directly enter the blood circulation.
How does CBD interacts with the body?
The endocannabinoid system (ECS) is a complex system that comprises receptors and maintains homeostasis. ECS maintains the functions of CNS and the immune system. CBD interacts with ECS receptors and contribute to improvement in clinical symptoms, such as chronic pain, headache, etc.
ECS comprises three major constituents, such as:
- CB1 and CB2 receptors
- Endocannabinoids
- Enzymes
CBD influence the endocannabinoid system by interacting with these receptors. In Lyme disease, CBD can help reduce the clinical symptoms, such as pain, joint tenderness, insomnia, etc, by modulating the endocannabinoid system.
What is the link between CBD and Lyme disease?
Even though, CBD cannot eliminate the bacteria, it can help alleviate the chronic symptoms exhibited by patients with Post-Treatment Lyme Disease Syndrome. Persistent inflammation and dysfunctional immune system can contribute to the clinical manifestations of Lyme disease, even after antibiotic therapy. At this stage, CBD can be supportive.
CBD can have anti-inflammatory and analgesic effects through its effect on the ECS system, reducing the pain in the joints and muscles. CBD modulates the GABA receptors and interfere with the brain processes, such as sleeping disorders, anxiety, etc.
According to many Lyme patients who have used CBD as a supplement to their treatment process, most have been able to get better sleep and less pain. The association of CBD with Lyme disease can help in relieving symptoms and may prove to be a useful alternative therapeutic option for managing long term symptoms of Lyme disease.
Uses of CBD in Lyme disease
- CBD has analgesic effect and helps in reducing pain by acting on pain receptors.
- Frequent inflammation in Lyme disease can result in several clinical symptoms that helps in reducing swelling. CBD control the release of pro-inflammatory chemicals and regulate the immune system.
- Neurological manifestations occur in Lyme disease in the later stages. CBD interacts with the receptors in the brain and influence the release of neurotransmitters.
- CBD helps in maintaining the balance of the immune system by regulating the production of cytokines.
- CBD can promote relaxation, leading to better sleep.
What is the route of administration of CBD in Lyme disease patients?
Cannabidiol is available in several forms, and it is vital to choose a proper route to cope with different Lyme disease symptoms. Sublingual administration is the most preferred route, in which oils or tinctures are put under the tongue. The mucous membrane will absorb the drug (within 15-30 minutes) and provide relief.
Oral administration of CBD includes capsules, gummies, or edibles that provides a long-lasting relief. CBD can also be applied topically, in the form of creams or ointments, at the site of localized pain. Topical products can help with joint stiffness or muscle pain.
A new form is transdermal CBD patches that administer a precise, constant amount of CBD over some time by introducing it through the skin into the bloodstream. Such application is convenient to the patient with regular symptoms.
Sublingual and topical administration are the most efficient and popular in Lyme disease patients. One should definitely seek medical advice and learn the most optimal route of administration, which suits the personal needs.
Can CBD cause any side effects in patients with Lyme disease?
There is a possibility of certain side effects among patients, especially when used along with other medicines. Lyme disease patients could be more sensitive due to pre-existing inflammation and immune system dysfunction.
There is a possibility of drug interaction, especially when taken with an analgesic or an anti-inflammatory drug. It is medically advisable that Lyme patients begin with a low dose and monitor the response. A significant number of Lyme patients can have good tolerance of CBD and find it as one of the effective complementary therapies.
Conclusion:
- CBD has emerged as an alternative treatment option for managing the clinical symptoms of Lyme disease.
- It can help in modulating the immune response and help to alleviate various clinical symptoms of Lyme disease.
- Several routes are available for administration, such as topical, oral, transdermal, tinctures, etc, that can be chosen according to the individual needs.
References:
- Project CBD. What is CBD? [Internet]. Project CBD; [cited 2025 Jun 25]. Available from:https://projectcbd.org/what-is-cbd/
- Grinspoon P. Cannabidiol (CBD) — what we know and what we don’t [Internet]. Harvard Health Blog. 2018 Aug 24 [cited 2025 Jun 25]. Available from:https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-201808242496
- Kicman A, Skonieczna-Żydecka K. A review of cannabidiol’s potential therapeutic effects in mental health disorders. Front Psychiatry [Internet]. 2023 [cited 2025 Jun 25];14:10458707. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10458707/
- Abuhasira R, Schleider LBL. Medical Cannabis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan– [cited 2025 Jun 25]. Available from:https://www.ncbi.nlm.nih.gov/books/NBK556048/