
Lyme disease is a common tick-borne disease that affects majority of the people. There are different types of ticks that carries pathogens. These bacteria that reside within the ticks are capable of causing various infections, such as cat-scratch fever, anaplasmosis, tick-borne encephalitis, etc. Have you heard of Rocky Mountain spotted fever?
Rocky Mountain spotted fever is a bacterial infection, which is spread through a tick bite. Both Lyme disease and Rocky Mountain spotted fever are transmitted through ticks, but caused by different bacteria. In this blog, we will discuss the key differences between the two tick-borne conditions.
What is Lyme disease?
Lyme disease is a bacterial infection, which is caused by the bacterium “Borrelia burgdorferi”. It affects individuals, who are residing in Northeast, and upper Midwest regions. The tick attaches to the host surface and feeds on human blood. The chances of infection can be reduced if ticks are removed within 24 hours.
Clinical symptoms:
- Musculoskeletal pain
- Arthritis
- Facial nerve paralysis
- Skin rashes
Treatment options:
Antibiotics are prescribed for a period of 10-14 days to relieve the clinical symptoms. Antibiotic treatment depends on several factors, such as
- Clinical symptoms
- Patient’s age
- Existing allergies
- Pregnancy

Antibiotics such as amoxicillin, doxycycline, cephalosporin, etc are used to manage the symptoms of Lyme disease.
What is Rocky Mountain spotted fever?
Rocky Mountain spotted fever is a tick-borne infection, which is caused by the bacterium, “Rickettsia rickettsii. Mostly, RSMF occurs during the months of April-September. The following ticks are responsible for transmitting the bacteria.
American dog tick |
Rocky mountain wood tick |
Brown dog tick |
Lone star tick |
Clinical symptoms:
Non-itchy skin rashes that begin on the arms, hands, and legs. These rashes comprise pink spots that occur within 5-10 days after the tick bite.
- Dilemma
- Sore throat
- Body pain and chills
- Reduced appetite

The bacteria affect the endothelial cells that line the small and medium vessels, leading to systemic symptoms. The bacterial entry can result in downregulation of the immune system.
When the endothelial cells are affected, it can cause
- Inflammation
- Changes in vascular permeability
- Loss of barrier integrity
Antibiotics, such as doxycycline are considered the treatment option for RSMF. Doxycycline is recommended for all patients, particularly those under 8 years, and pregnant ladies. People recover from clinical symptoms, such as fever within 24-48 hours. Individuals, who are experiencing chronic symptoms require longer duration of treatment. The mortality rate of RSMF ranges between 20-30% without proper antibiotic therapy.
Diagnosis of RSMF:
Blood tests and skin tests are used to diagnose RSMF. Your blood tests may not be positive for 7-10 days. To confirm the disease, blood test has to be repeated. In skin test, a small sample of skin is obtained to check for the signs.
How does Lyme disease differ from Rocky Mountain spotted fever?
In contrast to Lyme disease, Rocky Mountain spotted fever has a higher mortality rate. Lyme disease is caused by the bacterium, “Borrelia burgdorferi”, whereas RSMF is caused by “Rickettsia rickettsii”. Despite being tick-borne diseases, these two conditions have a huge difference in the nature of causative agents, geographic distribution, clinical presentation and even possible complications.
Lyme disease is caused by black-legged ticks (lxodes scapularis), whereas RMSF is caused by the American dog tick. Lyme disease normally presents clinically with a slowly enlarging erythema migrans rash and flu-like symptoms. When left untreated, it can cause neurologic, cardiac, and joint complications. The clinical symptoms of RSMF include fever, maculopapular rashes, and hepatitis.
The other important difference is the progression and severity of disease. The course of Lyme disease tends to be more indolent, but the RMSF can quickly result in multi-organ failure. Treatment of RMSF is correlated with increased mortality, whereas Lyme disease rarely causes death.
How to stay protected from tick bites?
A personal protection strategy must be ensured to protect from tick-borne illnesses, including Lyme disease and Rocky Mountain Spotted Fever (RMSF). Ticks are usually found in grassy or wooded areas. Protective clothing, like long-sleeved shirts, long pants and high socks can protect from tick bites.
Measures, like tucking pants into socks and wearing light-colored clothes can prevent tick bites to an extent. EPA-registered insect repellants can be applied on the skin and are even considered safe for pregnant women. After the outdoor activities, sites like hairline, ears, arm-pits, waistline, and groin region must be inspected for ticks.
If ticks are detected, tweezers can be used to remove them by holding it near to the skin and applying an upward pressure. The infected site can be washed with an antiseptic. The pets can also become a source of ticks. Hence, they must be safeguarded with the help of veterinarian approved tick prevention measures. Hence, these measures can be taken to prevent the occurences of Lyme disease and RSMF.
Conclusion:
Although, both RSMF and Lyme disease are spread through tick bites, they differ in terms of causes and severity. When RSMF is left untreated, life-threatening complications can occur. Hence, early detection and prompt treatment are necessary for managing both Lyme disease and RMSF.
References:
Centers for Disease Control and Prevention. Lyme disease: About Lyme disease [Internet]. Atlanta (GA): CDC; 2024 [cited 2025 Jul 10]. Available from: https://www.cdc.gov/lyme/about/index.html
Johns Hopkins Medicine. Rocky Mountain spotted fever [Internet]. Baltimore (MD): Johns Hopkins Medicine; c2024 [cited 2025 Jul 10]. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/rocky-mountain-spotted-fever
Osterhoudt KC, Zaoutis LB. Rocky Mountain Spotted Fever. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan– [cited 2025 Jul 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430881/
Centers for Disease Control and Prevention. Clinical care for healthcare providers: Rocky Mountain spotted fever (RMSF) [Internet]. Atlanta (GA): CDC; 2023 [cited 2025 Jul 10]. Available from: https://www.cdc.gov/rocky-mountain-spotted-fever/hcp/clinical-care/index.html